(Z)-Benzyl (2-Amino-2-(hydroxyimino)ethyl)carbamate

Ref. TR-B131220

Product Information

• Name: (Z)-Benzyl (2-Amino-2-(hydroxyimino)ethyl)carbamate
• Synonyms: benzyl N-[(2Z)-2-amino-2-hydroxyiminoethyl]carbamate

Description

Applications (Z)-Benzyl (2-Amino-2-(hydroxyimino)ethyl)carbamate is an intermediate used in the synthesis of N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide (H950690), which is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.
References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)

• Brand: TRC

Chemical properties

• Molecular weight: 223.228
• Formula: C₁₀H₁₃N₃O₃
• Color/Form: Neat
• InChI: InChI=1S/C10H13N3O3/c11-9(13-15)6-12-10(14)16-7-8-4-2-1-3-5-8/h1-5,15H,6-7H2,(H2,11,13)(H,12,14)
• InChI key: InChIKey=ZBXIEJDYVHPGMD-UHFFFAOYSA-N
• SMILES: N/C(CNC(=O)OCc1ccccc1)=N\O