Benzo[b]thien-2-yl Ketone (Zileuton Impurity)

CAS: 97978-07-9

Ref. TR-B207710

Product Information

• Name: Benzo[b]thien-2-yl Ketone (Zileuton Impurity)
• Synonyms: 2-(Benzo[b]thien-2-oyl)benzo[b]thiophene, Zileuton Related Compound B
• CAS: 97978-07-9

Description

Applications Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).
References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. & Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)

• Brand: TRC

Chemical properties

• Molecular weight: 294.39
• Formula: C₁₇H₁₀OS₂
• Color/Form: Neat
• InChI: InChI=1S/C17H10OS2/c18-17(15-9-11-5-1-3-7-13(11)19-15)16-10-12-6-2-4-8-14(12)20-16/h1-10H
• InChI key: InChIKey=XGEOFOPAAWHTSM-UHFFFAOYSA-N
• SMILES: O=C(c1cc2ccccc2s1)c1cc2ccccc2s1