(2R,3R,4R,5R)-5-(4-(Benzoyloxy)-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl Benzoate

Ref. TR-B208480

Product Information

• Name: (2R,3R,4R,5R)-5-(4-(Benzoyloxy)-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl Benzoate

Description

Applications (2R,3R,4R,5R)-5-(4-(Benzoyloxy)-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl Benzoate is an intermediate in synthesizing PSI 6130 (P839680), which is an experimental treatment for hepatitis C. PSI 6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI 6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.
References Clark, J., et al.: J. Med. Chem., 48, 5504 (2005); Stuyver, L., et al.: Antiviral Chem. Chem., 17, 79 (2006)

• Brand: TRC

Chemical properties

• Molecular weight: 572.537
• Formula: C₃₁H₂₅FN₂O₈
• Color/Form: White Powder
• InChI: InChI=1S/C31H25FN2O8/c1-31(32)25(42-28(37)22-15-9-4-10-16-22)23(19-39-26(35)20-11-5-2-6-12-20)40-29(31)34-18-17-24(33-30(34)38)41-27(36)21-13-7-3-8-14-21/h2-18,23,25,29H,19H2,1H3/t23-,25-,29-,31-/m1/s1
• InChI key: InChIKey=LDVLLESOZSFZAF-RDWHIKKYSA-N
• SMILES: C[C@@]1(F)[C@H](OC(=O)c2ccccc2)[C@@H](COC(=O)c2ccccc2)O[C@H]1n1ccc(OC(=O)c2ccccc2)nc1=O