Bivalirudin-(D-Phe-12) (Bivalirudin Impurity B)

Ref. TR-B591675

Product Information

• Name: Bivalirudin-(D-Phe-12) (Bivalirudin Impurity B)
• Synonyms: Bivalirudin Impurity B, D-Phenylalanyl-L-prolyl-L-arginyl-L-prolyl-L-glycyl-L-glycyl-L-glycyl-L-glycyl-L-asparaginyl-L-glycyl-L-α-aspartyl-D-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucine Trifluoroacetic Acid Salt

Description

Applications Bivalirudin-(D-Phe-12) is an impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012);

• Brand: TRC

Chemical properties

• Molecular weight: 2180.28
• Formula: C₉₈H₁₃₈N₂₄O₃₃•xC₂HF₃O₂
• Color/Form: Off White Solid
• InChI: InChI=1S/C98H140N24O33.C2HF3O2/c1-5-54(4)84(86(143)85(142)70-21-13-37-120(70)94(151)64(31-35-82(138)139)113-89(146)62(29-33-80(134)135)115-116-67(42-57-24-26-60(125)27-25-57)91(148)108-58(51-123)40-53(2)3)114-88(145)61(28-32-79(132)133)112-90(147)63(30-34-81(136)137)118-156(119-68(96(153)154)43-56-18-10-7-11-19-56)97(155)69(45-83(140)141)111-78(131)50-106-87(144)66(44-73(99)126)110-77(130)49-105-75(128)47-103-74(127)46-104-76(129)48-107-92(149)71-22-14-38-121(71)95(152)65(20-12-36-102-98(100)101)117-122-39-15-23-72(122)93(150)109-59(52-124)41-55-16-8-6-9-17-55;3-2(4,5)1(6)7/h6-11,16-19,24-27,51-54,58-59,61-72,84,115-119,125H,5,12-15,20-23,28-50H2,1-4H3,(H2,99,126)(H,103,127)(H,104,129)(H,105,128)(H,106,144)(H,107,149)(H,108,148)(H,109,150)(H,110,130)(H,111,131)(H,112,147)(H,113,146)(H,114,145)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,140,141)(H,153,154)(H4,100,101,102);(H,6,7)/t54-,58-,59-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,84-;/m0./s1/i156+1