Product Information
Name:
(R)-(+)-Blebbistatin O-Benzoate
Synonyms:
- (R)-3a-(Benzoyloxy)-1,2,3,3a-tetrahydro-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Description:
Applications (R)-(+)-Blebbistatin O-Benzoate is a derivative of Blebbistatin (B592495). (R)-(+)-Blebbistatin is a 1-phenyl-2-pyrrolidinone derivative and a selective inhibitor of non-muscle myosin II (1, 2, 3). It blocks cell blebbing rapidly and reversibly and also disrupts directed cell migration and cytokinesis in vertebrate cell. (R)-(+)-Blebbistatin can also inhibit contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (R)-(+)-Blebbistatin is suitable as a negative control for (S)-(-)-Blebblastatin.
References (1) Straight, A.F., et al.: Science (2003) 299: 1743-7(2) Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun (2004) 313: 992-7 (3) Kovacs, M., et al.: J. Biol. Chem. (2004) 279: 35557-63
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
396.44
Formula:
C25H20N2O3
Color/Form:
Orange Solid
InChI:
InChI=1S/C25H20N2O3/c1-17-12-13-20-21(16-17)26-24-25(22(20)28,30-23(29)18-8-4-2-5-9-18)14-15-27(24)19-10-6-3-7-11-19/h2-13,16H,14-15H2,1H3/t25-/m0/s1
InChI key:
InChIKey=ICIURMLAMQGRRU-VWLOTQADSA-N
SMILES:
Cc1ccc2c(c1)C(=O)[C@@]1(OC(=O)c3ccccc3)CCN(c3ccccc3)C1=N2
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:
