(L)-2-[(t-Boc)amino]-2-[(5-Fluoresceinyl)aminocarbonyl]ethyl Methanethiosulfonate

CAS: 1042688-20-9

Ref. TR-B619050

Product Information

• Name: (L)-2-[(t-Boc)amino]-2-[(5-Fluoresceinyl)aminocarbonyl]ethyl Methanethiosulfonate
• Synonyms: [(2S)-3-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxopropyl] methanesulfonate

Description

Stability Light Sensitive
Applications A thiol specific fluorescent probe useful for ion channel and protein topology research. The recently available MTS-fluorophores may find application in the real-time monitoring of conformational changes, since fluorophores coupled to introduced cysteines can change their fluorescence during a conformational change. Fluorescence lifetime may also yield information regarding distances and molecular motion in a protein molecule.Fluorescence: max. Abs. 492nm; max. Em. 515nm; e x 10-3: 75
References Mannuzzu, L.M., et al.: Science, 271, 213 (1996), Goulett, C.C., et al.: JBC, 273, 45, 30012 (1998), Adams, C.M., et al.: JBC, 273, 46, 30204 (1998)

• Brand: TRC

Chemical properties

• Molecular weight: 612.60
• Formula: C₂₉H₂₈N₂O₁₁S
• Color/Form: Neat
• InChI: InChI=1S/C29H28N2O11S/c1-28(2,3)42-27(36)31-22(14-39-43(4,37)38)25(34)30-15-5-8-19-18(11-15)26(35)41-29(19)20-9-6-16(32)12-23(20)40-24-13-17(33)7-10-21(24)29/h5-13,22,32-33H,14H2,1-4H3,(H,30,34)(H,31,36)/t22-/m0/s1
• InChI key: InChIKey=ZZUGASBFWLQFLK-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NC(CSS(C)(=O)=O)C(=O)Nc1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1