1-tert-Butyl 3-Ethyl 5-methyl 2-((2-((tert-Butoxycarbonyl)amino)ethoxy)methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate

CAS: 2512209-23-1

Ref. TR-B701338

Product Information

• Name: 1-tert-Butyl 3-Ethyl 5-methyl 2-((2-((tert-Butoxycarbonyl)amino)ethoxy)methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate
• Synonyms: 1-O-tert-butyl 5-O-ethyl 3-O-methyl 4-(2-chlorophenyl)-2-methyl-6-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxymethyl]-4H-pyridine-1,3,5-tricarboxylate
• Brand: TRC
• Description: Applications 1-tert-Butyl 3-Ethyl 5-methyl 2-((2-((tert-Butoxycarbonyl)amino)ethoxy)methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate is an intermediate in the synthesis of 3-O-Desethyl-5-O-desmethyl Amlodipine (D291305). 3-O-Desethyl-5-O-desmethyl Amlodipine is an impurity of Amlodipine (A633495), which is a dihydropyridine calcium channel blocker.References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)

Chemical properties

• Molecular weight: 609.107
• Formula: C₃₀H₄₁ClN₂O₉
• Color/Form: Neat
• InChI: InChI=1S/C30H41ClN2O9/c1-10-40-26(35)24-21(17-39-16-15-32-27(36)41-29(3,4)5)33(28(37)42-30(6,7)8)18(2)22(25(34)38-9)23(24)19-13-11-12-14-20(19)31/h11-14,23H,10,15-17H2,1-9H3,(H,32,36)
• InChI key: InChIKey=VLHQPRHTUQTHPK-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(COCCNC(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)C(C)=C(C(=O)OC)C1c1ccccc1Cl