(3R,4R)-tert-Butyl 4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

CAS: 1450663-24-7

Ref. TR-B811316

Product Information

• Name: (3R,4R)-tert-Butyl 4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
• CAS: 1450663-24-7

Description

Applications (3R,4R)-tert-Butyl 4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate is an intermediate in the synthesis of 5,6-Dihydro CP-690550 (D450240), an impurity of CP-690550 (C781350), a pyrrolo[2,3-d]pyrimidine derivative, as Janus kinase inhibitor for treatment of rheumatoid arthritis.
References Sheiner, L., et al.: Clin. Pharmacol. Ther., 25, 358 (1979); Dayneka, N., et al.: J. Pharmacokin. Biopharm., 21, 457 (1993); Changelian, P., et al.: Science, 302, 875 (2003); Lee, H., et al.: Clin. Pharmacol. Ther., 73, 348 (2003); Hutmacher, M., et al.: J. Clin. Pharmacol., 47, 238 (2007)

• Brand: TRC

Chemical properties

• Molecular weight: 345.44
• Formula: C₁₈H₂₇N₅O₂
• InChI: InChI=1S/C18H27N5O2/c1-12-7-9-23(17(24)25-18(2,3)4)10-14(12)22(5)16-13-6-8-19-15(13)20-11-21-16/h6,8,11-12,14H,7,9-10H2,1-5H3,(H,19,20,21)/t12-,14+/m1/s1
• InChI key: InChIKey=MNUYILMTXWFWMH-OCCSQVGLSA-N
• SMILES: C[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1N(C)c1ncnc2[nH]ccc12