Cabozantinib Des-O-fluoroaniline

CAS: 849217-77-2

Ref. TR-C051610

Product Information

• Name: Cabozantinib Des-O-fluoroaniline
• Synonyms: 1-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropanecarboxylic Acid

Description

Applications Cabozantinib Des-O-fluoroaniline is a degradation product of Cabozantinib(C051500). Cabozantinib is a small molecule C-Met modulator. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.
References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010); Wu, C., et al.: J. Pharm. Biomed. Anal., 98, 356 (2014)

• Brand: TRC

Chemical properties

• Molecular weight: 408.4
• Formula: C₂₂H₂₀N₂O₆
• Color/Form: Neat
• InChI: InChI=1S/C22H20N2O6/c1-28-18-11-15-16(12-19(18)29-2)23-10-7-17(15)30-14-5-3-13(4-6-14)24-20(25)22(8-9-22)21(26)27/h3-7,10-12H,8-9H2,1-2H3,(H,24,25)(H,26,27)
• InChI key: InChIKey=HXGYPQKHBCZWKO-UHFFFAOYSA-N
• SMILES: COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)O)CC4)cc3)c2cc1OC