Canadine

CAS: 522-97-4

Ref. TR-C175175

Product Information

• Name: Canadine
• Synonyms: 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-, Berberine, 9-deoxy-16,17-dihydro- (6CI), Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)- (7CI,8CI), Berberine, tetrahydro-, NSC 36351, NSC 94918, Tetrahydroberberine, Tetrahydroumbellatine, Xanthopuccine, dl-Canadine, dl-Tetrahydroberberine, (+/-)-Tetrahydroberberine, (±)-Tetrahydroberberine, 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-, Berberine, 9-deoxy-16,17-dihydro-, Berberine, tetrahydro-, Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)-, Tetrahydroberineper
• CAS: 522-97-4

Description

Applications Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.
References Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006), Sun., et al.: Br. J. Pharmcol., 158, 1302 (2009), Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2010),

• Brand: TRC

Chemical properties

• Molecular weight: 339.38
• Formula: C₂₀H₂₁NO₄
• Color/Form: Light Yellow to Green Solid
• InChI: InChI=1S/C20H21NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3
• InChI key: InChIKey=VZTUIEROBZXUFA-UHFFFAOYSA-N
• SMILES: COc1ccc2c(c1OC)CN1CCc3cc4c(cc3C1C2)OCO4