CHIR-99021 Hydrochloride

CAS: 1797989-42-4

Ref. TR-C292150

Product Information

• Name: CHIR-99021 Hydrochloride
• Synonyms: CHIR 911 Hydrochloride, CT 99021 Hydrochloride, CHIR99021
• CAS: 1797989-42-4

Description

Applications CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. GSK-3α/β inhibitor
References Ring, et al.: Diabetes, 52, 588 (2003); Tighe, et al.: Cell Biol., 8, 34 (2007); Pan, et al.: Neuropsychopharmacology, 36, 1397 (2011);

• Brand: TRC

Chemical properties

• Molecular weight: 501.8
• Formula: C₂₂H₁₉Cl₃N₈
• Color/Form: Neat
• SMILES: Cc1cnc(-c2c[nH]c(=NCCN=c3ccc(C#N)c[nH]3)nc2-c2ccc(Cl)cc2Cl)[nH]1.Cl