(17R)-4’-Chloro-5’-ethyl-9-fluoro-11b-hydroxy-16b-methylspiro[androsta-1,4-diene-17,2’(3’H)-furan]-3,3’-dione

CAS: 1486466-31-2

Ref. TR-C366115

Product Information

• Name: (17R)-4’-Chloro-5’-ethyl-9-fluoro-11b-hydroxy-16b-methylspiro[androsta-1,4-diene-17,2’(3’H)-furan]-3,3’-dione
• Synonyms: Clobetasol Propionate 17alpha-spiro Compound, 9a-Fluoro-11b-hydroxy-16b-methyl-3-oxoandrosta-1,4-diene-17(R)-spiro-2'-[4'-chloro-5'-ethylfuran-3'(2'H)-one,(17R)-4′-Chloro-5′-ethyl-9-fluoro-11β-hydroxy-16β-methylspiro[androsta-1,4-diene-17,2′(3′H)-furan]-3,3′-dione, Clobetasol Propionate 17α-spiro Compound, (17R)-4'-Chloro-5'-ethyl-9-fluoro-11beta-hydroxy-16beta-methylspiro[androsta-1,4-diene-17,2'(3'H)-furan]-3,3'-dione, USP Clobetasol propionate Related Compound A, Ph Eur Clobetasol Propionate Impurity J, CCI18747, CCI6990, Clobetasol-17-propionate, CCI1822, Clobetasol-17-propionate isomer, 21-desoxybetamethasone-17-propionate, 16-ene, Ethylenic acid, USP Clobetasol propionate Related Compound A
• CAS: 1486466-31-2

Description

Applications (17R)-4’-Chloro-5’-ethyl-9-fluoro-11β-hydroxy-16β-methylspiro[androsta-1,4-diene-17,2’(3’H)-furan]-3,3’-dione, is an impurity of Clobetasol (C583490), a topical corticosteroid, and a Glucocorticoid, used as an anti-inflammatory agent.
References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

• Brand: TRC

Chemical properties

• Molecular weight: 448.95
• Formula: C₂₅H₃₀ClFO₄
• Color/Form: White to Off-White Solid
• InChI: InChI=1S/C25H30ClFO4/c1-5-18-20(26)21(30)25(31-18)13(2)10-17-16-7-6-14-11-15(28)8-9-22(14,3)24(16,27)19(29)12-23(17,25)4/h8-9,11,13,16-17,19,29H,5-7,10,12H2,1-4H3/t13-,16-,17-,19-,22-,23-,24-,25-/m0/s1
• InChI key: InChIKey=LXZPFTQONPQBQD-TUZVJILZSA-N
• SMILES: CCC1=C(Cl)C(=O)[C@@]2(O1)[C@@H](C)C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C