2-Chloroethyl Methanethiosulfonate

CAS: 13700-02-2

Ref. TR-C366125

Product Information

• Name: 2-Chloroethyl Methanethiosulfonate
• Synonyms: Methanesulfonothioic Acid S-(2-Chloroethyl) Ester, 2-Chloro-ethanethiol Methanesulfonate

Description

Stability Moisture Sensitive
Applications Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor.
References Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996), Holmgren, M. et al: Neuropharmacology, 35, 797 (1996) Chahine, M. et al.: Biochemical & Biophysical Res. Commun., 233, 606 (1997), Ehrlich, B.E., et al.: J. Gen. Physiol., 109, 255 (1997), Rassendren, F., et al.: The EMBO Journal, 16, 3446 (1997), Egan, T.M., et al.: The Journal of Neuroscience, 18(7), 2350 (1998), Lin, C.-W. and Tsung-Yu, C.: J. Gen. Physiol., 116, 535 (2000)

• Brand: TRC

Chemical properties

• Molecular weight: 174.67
• Formula: C₃H₇ClO₂S₂
• Color/Form: Clear Colourless Oil
• InChI: InChI=1S/C3H7ClO2S2/c1-8(5,6)7-3-2-4/h2-3H2,1H3
• InChI key: InChIKey=LMGGUMRZPMEEEK-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)SCCCl