Cloticasone Propionate-d3

CAS: 80486-69-7

Ref. TR-C369162

Product Information

• Name: Cloticasone Propionate-d3
• Synonyms: 5-Chloromethyl 6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-(propionyloxy-d3)-androsta-1,4-diene-17beta-carbothioate, (6alpha.,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy-d3)androsta-1,4-diene-17-carbothioic Acid S-(Chloromethyl) Ester, CCI 18773-d3, (6a,11b,16a,17a)-17-(((Chloromethyl)thio)carbonyl)-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl Propionate, (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid S-(Chloromethyl) Ester, androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(chloromethyl) ester, (6alpha,11beta,16alpha,17alpha)-, Cloticasone Propionate
• CAS: 80486-69-7

Description

Applications An intermediate in the synthesis of Fluticasone Propionate.
References Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)

• Brand: TRC

Chemical properties

• Molecular weight: 520.044
• Formula: C₂₅H₂₈D₃ClF₂O₅S
• Color/Form: White to Pale Yellow Solid
• InChI: InChI=1S/C25H31ClF2O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1/i1D3
• InChI key: InChIKey=MVLBCBPGBUAVJQ-GGMSSNLNSA-N
• SMILES: [2H]C([2H])([2H])CC(=O)O[C@]1(C(=O)SCCl)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C