5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid

CAS: 162758-35-2

Ref. TR-C377830

Product Information

• Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid
• Synonyms: 1-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic Acid, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic Acid, 1-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid, 1H-Pyrazole-3-carboxylic acid, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-, 5-(4-Chloro-Phenyl)-1-(2,4-Dichloro-Phenyl)-4-Methyl-1H-Pyrazole-3-Carboxylic Acid, 5-(4-Chlorophenyl)-1-(2,4-Dichlorophenyl)-4-Methy-1H-Pyrazole-3-Carboxylic Acid, 5-(4-Chlorophenyl)-1-(2,4-Dichlorophenyl)-4-Methyl-1H-Pyrazole-3-Carboxylic Acid, Rimonabant Carboxylic Acid, Rimonabantacid, Rimonabat Acomplia
• CAS: 162758-35-2

Description

Applications 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid is used in the preparation of biarylpyrazole based derivatives as cannabinoid CB1 receptor antagonists. It is metabolite M9 of Rimonabant (R517800), an antiobesity agent.
References Kang, S.Y. et al.: Bioorg. Med. Chem. Lett., 18, 2385 (2008); Fulp, A. et al.: Bioorg. Med. Chem. Lett., 21, 5711 (2011); Bergstrom, M.A. et al.: Drug Metab. and Dispos., 39, 1823 (2011);

• Brand: TRC

Chemical properties

• Molecular weight: 381.64
• Formula: C₁₇H₁₁Cl₃N₂O₂
• Color/Form: Neat
• InChI: InChI=1S/C17H11Cl3N2O2/c1-9-15(17(23)24)21-22(14-7-6-12(19)8-13(14)20)16(9)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,23,24)
• InChI key: InChIKey=CYAYCOCJAVHQSD-UHFFFAOYSA-N
• SMILES: Cc1c(C(=O)O)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1