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(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
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(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

CAS: 1001264-89-6

Ref. TR-C377870

Estimated delivery in United States, on Wednesday 9 Dec 2020

Product Information

Name:
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
Synonyms:
  • GDC-0068
  • Ipatasertib
  • RG 7440
  • Gdc-0068
Description:

Applications (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
References Jie, L., et al.: Clin. Cancer. Res., 10, 1078 (2013);

Long term storage:
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Chemical properties

Molecular weight:
458.0
Formula:
C24H32ClN5O2
Color/Form:
Peach Solid
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Hazard Info

UN Number:
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Forbidden to fly:
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LQ:

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