2-​[2-​[[4-​[(5S)​-​5-​[[[(5-Chloro-​2-​thienyl)​carbonyl]​amino]​methyl]​-​2-​oxo-​3-​oxazolidinyl]​phenyl]​amino]​ethoxy]​-acetic Acid Hydrochloride

CAS: 931117-61-2

Ref. TR-C421840

Product Information

• Name: 2-​[2-​[[4-​[(5S)​-​5-​[[[(5-Chloro-​2-​thienyl)​carbonyl]​amino]​methyl]​-​2-​oxo-​3-​oxazolidinyl]​phenyl]​amino]​ethoxy]​-acetic Acid Hydrochloride
• Synonyms: Rivaroxaban Impurity A Hydrochloride
• CAS: 931117-61-2

Description

Stability Hygroscopic
Applications 2-​[2-​[[4-​[(5S)​-​5-​[[[(5-​chloro-​2-​thienyl)​carbonyl]​amino]​methyl]​-​2-​oxo-​3-​oxazolidinyl]​phenyl]​amino]​ethoxy]​-acetic Acid Hydrochloride is a metabolite of Rivaroxaban (R538000) which is a novel antithrombotic agent. Rivaroxaban is also a highly potent and selective, direct FXa inhibitor.
References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005)

• Brand: TRC

Chemical properties

• Molecular weight: 453.903646
• Formula: C₁₉H₂₀ClN₃O₆S•HCl
• Color/Form: White Light Red
• InChI: InChI=1S/C19H20ClN3O6S.ClH/c20-16-6-5-15(30-16)18(26)22-9-14-10-23(19(27)29-14)13-3-1-12(2-4-13)21-7-8-28-11-17(24)25;/h1-6,14,21H,7-11H2,(H,22,26)(H,24,25);1H/t14-;/m0./s1
• InChI key: InChIKey=UFNIIYAHXMBQSV-UQKRIMTDSA-N
• SMILES: Cl.O=C(O)COCCNc1ccc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)cc1