a-(4-Chlorophenyl)-2-ethyl-1,3-dioxolane-2-acetonitrile

CAS: 55474-41-4

Ref. TR-C422235

Product Information

• Name: a-(4-Chlorophenyl)-2-ethyl-1,3-dioxolane-2-acetonitrile
• Synonyms: 1,3-Dioxolane-2-acetonitrile, a-(4-chlorophenyl)-2-ethyl-, (?)-(4-Chlorophenyl)(2-ethyl-1,3-dioxolan-2-yl)acetonitrile, (4-Chlorophenyl)(2-Ethyl-1,3-Dioxolan-2-Yl)Acetonitrile, 1,3-Dioxolane-2-acetonitrile, α-(4-chlorophenyl)-2-ethyl-, 2-(4-Chlorophenyl)-2-(2-ethyl-1,3-dioxolan-2-yl)acetonitrile, alpha-(4-Chlorophenyl)-2-ethyl-1,3-dioxolane-2-acetonitrile, α-(4-Chlorophenyl)-2-ethyl-1,3-dioxolane-2-acetonitrile

Description

Applications α-(4-Chlorophenyl)-2-ethyl-1,3-dioxolane-2-acetonitrile is an impurity of Pyrimethamine (P997240), a dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial.
References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983); Leport, C., et al.: Am. J. Med., 84, 94 (1988); McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998); Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004);

• Brand: TRC

Chemical properties

• Molecular weight: 251.71
• Formula: C₁₃H₁₄ClNO₂
• Color/Form: Neat
• InChI: InChI=1S/C13H14ClNO2/c1-2-13(16-7-8-17-13)12(9-15)10-3-5-11(14)6-4-10/h3-6,12H,2,7-8H2,1H3
• SMILES: CCC1(C(C#N)c2ccc(Cl)cc2)OCCO1