Clotiazepam-13C,d3

CAS: 1346599-72-1

Ref. TR-C587412

Product Information

• Name: Clotiazepam-13C,d3
• Synonyms: 5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-(methyl-13C,d3)-2H-thieno[2,3-e]-1,4-diazepin-2-one, Clozan-13C,d3, Rize-13C,d3, Rizen-13C,d3, 5-(o-Chlorophenyl)-7-ethyl-1-(methyl-13C,d3)-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one, Tienor-13C,d3, Trecalmo-13C,d3, Veratran-13C,d3, Y 6047-13C,d3, 1-(Methyl-13C,d3)-5-o-chlorophenyl-7-ethyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one
• CAS: 1346599-72-1

Description

Applications A labelled thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor.Controlled Substance.
References Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);

• Brand: TRC

Chemical properties

• Molecular weight: 322.83
• Formula: C₁₅CH₁₂D₃ClN₂OS
• Color/Form: Off-White to Pale Yellow Solid
• InChI: InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3/i2+1D3
• InChI key: InChIKey=CHBRHODLKOZEPZ-JVXUGDAPSA-N
• SMILES: [2H][13C]([2H])([2H])N1C(=O)CN=C(c2ccccc2Cl)c2cc(CC)sc21