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Product Information
Name:
Cobicistat-d8
Controlled Product
Synonyms:
- (3R,6R,9S)-2-Methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic-d8 Acid 5-Thiazolylmethyl Ester
CAS:
Description:
Applications Isotope labelled analogue of Cobicistat (C633150), a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.
References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
784.072
Formula:
C40H46D8N7O5S2
InChI:
InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32?,33?,36-/m0/s1/i18D2,19D2,20D2,21D2
InChI key:
InChIKey=ZCIGNRJZKPOIKD-YEWHTEBSSA-N
SMILES:
[2H]C1([2H])OC([2H])([2H])C([2H])([2H])N(CC[C@H](NC(=O)N(C)Cc2csc(C(C)C)n2)C(=O)NC(CCC(Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)C1([2H])[2H]
MDL:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-C633152 Cobicistat-d8
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