[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N’) Dichloridoplatinum(II)

CAS: 61848-66-6

Ref. TR-C987465

Product Information

• Name: [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N’) Dichloridoplatinum(II)
• Synonyms: Platinum, dichloro(1,2-cyclohexanediamine-N,N')-, [SP-4-2-(1R-trans)]-, Platinum, dichloro[(1R,2R)-1,2-cyclohexanediamine-kappaN,kappaN']-, (SP-4-2)- (9CI), (SP-4-2)-Dichloro[(1R,2R)-1,2-cyclohexanediamine-kappaN1,kappaN2]platinum, 1,2-Cyclohexanediamine, platinum complex, (1R-trans)-, 1,2-Diamminecyclohexane-dichloroplatinum(II), Dichloro((1R,2R)-trans-diaminocyclohexane)platinum(II), Dichloro((R,R)-1,2-diaminocyclohexane)platinum, Dichloro(1R,2R-1,2-diaminocyclohexane)platinum, Dichloro(1R,2R-cyclohexanediammine)platinum(II), Dichloro(trans-R,R-1,2-diaminocyclohexane)platinum, Dichloro(trans-l-1,2-cyclohexanediamine)platinum(II), Dichloro[(1R,2R)-1,2-cyclohexanediamine]platinum, Dichloro[(R,R)-1,2-cyclohexanediamine]platinum, Dichloro[trans-(-)-1,2-cyclohexanediamine]platinum(II), NSC 265460, cis-Dichlorobis((1R,2R)-cyclohexanediamine)platinum, [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N') Dichloridoplatinum(II),Platinum, dichloro[(1R,2R)-1,2-cyclohexanediamine-?N1,?N2]-, (SP-4-2)-, Platinum, dichloro[(1R,2R)-1,2-cyclohexanediamine-?N,?N']-, (SP-4-2)- (9CI), (SP-4-2)-Dichloro[(1R,2R)-1,2-cyclohexanediamine-?N1,?N2]platinum, Platinum, dichloro(1,2-cyclohexanediamine-?N,?N')-, [SP-4-2-[1R-(trans)]]-, Platinum, dichloro[(1R,2R)-1,2-cyclohexanediamine-kappaN1,kappaN2]-, (SP-4-2)-,

Description

Applications [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N’) dichloridoplatinum(II) is an impurity of Oxiplatin (O845075), third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y. et al.: Biomed. Pharmacther., 43, 261 (1989); Noji, M. et al.: J. Med. Chem., 24, 508 (1981); Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

• Brand: TRC

Chemical properties

• Molecular weight: 380.17
• Formula: C₆H₁₄Cl₂N₂Pt
• Color/Form: Neat
• InChI: , , , /q, , InChI=1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8, +2/p-2/t5-,6-, 2*1H, , , /m1.../s1, /h5-6H,1-4,7-8H2
• InChI key: InChIKey=PNNCIXRVXCLADM-SKSSAGQDSA-L