1-Cyclopropane Mycophenolic Acid

CAS: 125198-40-5

Ref. TR-C989230

Product Information

• Name: 1-Cyclopropane Mycophenolic Acid
• Synonyms: 3-(2-((4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)methyl)-1-methylcyclopropyl)propanoic Acid, 2-[(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)methyl]-1-methyl-cyclopropanepropanoic Acid
• CAS: 125198-40-5

Description

Applications 1-Cyclopropane Mycophenolic Acid is a non-active analogue of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.
References Senda, M., et al.: Transplantation, 60, 1143 (1995); Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996); Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999)

• Brand: TRC

Chemical properties

• Molecular weight: 334.36
• Formula: C₁₈H₂₂O₆
• Color/Form: Neat
• InChI: InChI=1S/C18H22O6/c1-9-12-8-24-17(22)14(12)15(21)11(16(9)23-3)6-10-7-18(10,2)5-4-13(19)20/h10,21H,4-8H2,1-3H3,(H,19,20)
• InChI key: InChIKey=QVUZLDOXUBRWHS-UHFFFAOYSA-N
• SMILES: COc1c(C)c2c(c(O)c1CC1CC1(C)CCC(=O)O)C(=O)OC2