Estimated delivery in United States, on Thursday 16 Jan 2025
Product Information
Name:
Dabrafenib-d9
Controlled Product
Synonyms:
- N-[3-[5-(2-aminopyrimidin-4-yl)-2-[2,2,2-trideuterio-1,1-bis(trideuteriomethyl)ethyl]thiazol-4-yl]-2-fluoro-phenyl]-2,6-difluoro-benzenesulfonamide
Description:
Applications Dabrafenib-d9 is the isotope labelled analog of Dabrafenib (D101000); an inhibitor of mutated BRAF kinase. Dabrafenib also has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.
References Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
528.62
Formula:
C23D9H11F3N5O2S2
Color/Form:
Neat
InChI:
InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)/i1D3,2D3,3D3
InChI key:
InChIKey=BFSMGDJOXZAERB-GQALSZNTSA-N
SMILES:
[2H]C([2H])([2H])C(c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1)(C([2H])([2H])[2H])C([2H])([2H])[2H]
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Technical inquiry about: TR-D101002 Dabrafenib-d9
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