(S)-N-Deacetyl Colchicine

CAS: 3476-50-4

Ref. TR-D198920

Product Information

• Name: (S)-N-Deacetyl Colchicine
• Synonyms: (7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one, (-)-7-Deacetylcolchicine, (-)-Deacetylcolchicine, (7S)-7-Amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one, (7S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one, Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (S)-, Colchicine, N-deacetyl-, Colchicine, deacetyl-, Desacetylcolchicine, N-Deacetylcolchicine, N-Desacetylcolchicine, NSC 201400, benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-
• CAS: 3476-50-4

Description

Applications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998), Alali, F., et al.: Phytochem. Anal., 19, 385 (2008), Chang, D., et al.: Bioorg. Med. Chem. Lett., 19, 4416 (2009),

• Brand: TRC

Chemical properties

• Molecular weight: 357.40
• Formula: C₂₀H₂₃NO₅
• Color/Form: Neat
• InChI: InChI=1S/C20H23NO5/c1-23-16-8-6-12-13(10-15(16)22)14(21)7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12/h6,8-10,14H,5,7,21H2,1-4H3/t14-/m0/s1
• InChI key: InChIKey=HFPMXDMZJUJZBX-AWEZNQCLSA-N
• SMILES: COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](N)CC2