16-Deacetylfusidic Acid γ-Lactone

CAS: 4701-54-6

Ref. TR-D199075

Product Information

• Name: 16-Deacetylfusidic Acid γ-Lactone
• Synonyms: 29-Nordammara-17(20),24-dien-21-oic acid, 3,11,16-trihydroxy-, ?-lactone, (3a,4a,8a,9ß,11a,13a,14ß,16ß)-, 29-Nor-8a,9ß,13a,14ß-dammara-17(20),24-dien-21-oic acid, 3a,11a,16ß-trihydroxy-, ?-lactone (7CI,8CI), 16-Deacetylfusidic acid ?-lactone, 16-O-Deacetylfusidic acid lactone, ent-(17Z)-3ß,11ß-Dihydroxy-4ß,8,14-trimethyl-18-nor-5ß,10a-cholesta-17(20),24-dieno-21(16a)-lactone, Deacetylfusidic acid 21,16-lactone

Description

Applications 16-Deacetylfusidic Acid γ-Lactone is a metabolite of the drug Fusidic Acid (F865500). Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.
References Collignon, P., et al.: Int. J. Antimicrob. Agents, 12, S45 (1999); Di Marco, R., et al.: J. Autoimmun., 13, 187 (1999); Price, C.T., et al.: J. Antimicrob., Chemother., 44, 57 (1999)

• Brand: TRC

Chemical properties

• Molecular weight: 456.6573
• Formula: C₂₉H₄₄O₄
• Color/Form: Neat
• InChI: InChI=1S/C29H44O4/c1-16(2)8-7-9-18-24-20-14-22(31)25-27(4)12-11-21(30)17(3)19(27)10-13-28(25,5)29(20,6)15-23(24)33-26(18)32/h8,17,19-23,25,30-31H,7,9-15H2,1-6H3/t17-,19-,20-,21+,22+,23-,25-,27-,28-,29-/m0/s1
• InChI key: InChIKey=WESBIDUQKXCXGS-WLLXWWBMSA-N
• SMILES: CC(C)=CCCC1=C2[C@H](C[C@@]3(C)[C@H]2C[C@@H](O)[C@H]2[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@@H]4CC[C@@]23C)OC1=O