Desethyl Azilsartan Medoxomil

CAS: 1417576-00-1

Ref. TR-D289258

Product Information

• Name: Desethyl Azilsartan Medoxomil
• Synonyms: 3-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2,3-dihydro-2-oxo-1H-benzimidazole-4-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester
• CAS: 1417576-00-1

Description

Applications Desethyl Azilsartan Medoxomil is an impurity from the synthesis of Azilsartan Medoxomil (A926910). Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).
References Radl, S., et al.: Org. Process. Res. Dev., 17), 77-86 (2013); Baker, W. & White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)

• Brand: TRC

Chemical properties

• Molecular weight: 540.48
• Formula: C₂₈H₂₀N₄O₈
• Color/Form: Neat
• InChI: InChI=1S/C28H20N4O8/c1-15-22(39-28(36)38-15)14-37-25(33)20-7-4-8-21-23(20)32(26(34)29-21)13-16-9-11-17(12-10-16)18-5-2-3-6-19(18)24-30-27(35)40-31-24/h2-12H,13-14H2,1H3,(H,29,34)(H,30,31,35)
• InChI key: InChIKey=MZPRTKPTVHPGEW-UHFFFAOYSA-N
• SMILES: Cc1oc(=O)oc1COC(=O)c1cccc2[nH]c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c12