Defluoro Atorvastatin Calcium Salt

CAS: 433289-83-9

Ref. TR-D289875

Product Information

• Name: Defluoro Atorvastatin Calcium Salt
• Synonyms: 1H-Pyrrole-1-heptanoic acid, ß,d-dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-, calcium salt (2:1), (ßR,dR)-, Desfluoroatorvastatin Calcium Salt

Description

Impurity Atorvastatin USP Related Compound A
Stability Hygroscopic
Applications Desfluoro Atorvastatin is an impurity in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Gupta, L. et al.: Spect. Acta. Mol. Biomol. Spect., 97, 495 (2012); Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),

• Brand: TRC

Chemical properties

• Molecular weight: 1119.36
• Formula: C₃₃H₃₅N₂O₅·Ca
• Color/Form: White To Off-White
• InChI: /m11./s1, /q, /h2*3-17,22,26-27,36-37H,18-21H2,1-2H3,(H,34,40)(H,38,39), +2/p-2/t2*26-,27-, , InChI=1S/2C33H36N2O5.Ca/c2*1-22(2)31-30(33(40)34-25-16-10-5-11-17-25)29(23-12-6-3-7-13-23)32(24-14-8-4-9-15-24)35(31)19-18-26(36)20-27(37)21-28(38)39