Deshydroxy Sotalol Hydrochloride

CAS: 16974-44-0

Ref. TR-D290055

Product Information

• Name: Deshydroxy Sotalol Hydrochloride
• Synonyms: Sotalol Hydrochloride Imp. A (EP), Sotalol Imp. A (EP), Sotalol USP Related Compound C, Sotalol USP RC C, N-[4-[2-[(1-Methylethyl)amino]ethyl]phenyl]-methanesulphonamide Hydrochloride, Sotalol Hydrochloride Imp. A (EP) as Hydrochloride, Sotalol Related Compound C as Hydrochloride, Sotalol Hydrochloride Impurity A as Hydrochloride, Sotalol Impurity A as Hydrochloride, Methanesulfonamide, N-[4-[2-[(1-methylethyl)amino]ethyl]phenyl]-, monohydrochloride, Methanesulfonamide, N-[4-[2-[(1-methylethyl)amino]ethyl]phenyl]-, hydrochloride (1:1)

Description

Applications Deshydroxy Sotalol Hydrochloride is an impurity in the synthesis of Sotalol (S677300), a potent α-adrenergic receptor antagonist. A class III antiarrythmic. It has been shown to prolong action potential and increases the refractory period.
References Uloth, et al.: J. Med. Chem., 9, 88 (1966), Groh, W.J., et al.: Chirality, 5, 8 (1993), Pasnani, J.S., et al.: J. Pharmacol. Exp. Ther., 271, 184 (1994),

• Brand: TRC

Chemical properties

• Molecular weight: 292.83
• Formula: C₁₂H₂₀N₂O₂S·ClH
• Color/Form: White
• InChI: /h4-7,10,13-14H,8-9H2,1-3H3, 1H, InChI=1S/C12H20N2O2S.ClH/c1-10(2)13-9-8-11-4-6-12(7-5-11)14-17(3,15)16
• InChI key: InChIKey=GPOMQHDZXSGJKB-UHFFFAOYSA-N
• SMILES: CC(C)NCCc1ccc(NS(C)(=O)=O)cc1.Cl