O-Desmethyl Apixaban Sulfate Sodium Salt

CAS: 1118765-14-2

Ref. TR-D290892

Product Information

• Name: O-Desmethyl Apixaban Sulfate Sodium Salt
• Synonyms: 4,5,6,7-Tetrahydro-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1-[4-(sulfooxy)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-carboxamide Sodium Salt

Description

Stability Hygroscopic
Applications O-Desmethyl Apixaban Sulfate is an impurity of Apixaban (A726700), is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation
References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);

• Brand: TRC

Chemical properties

• Molecular weight: 547.516
• Formula: C₂₄H₂₂N₅NaO₇S
• Color/Form: White To Off-White
• InChI: InChI=1S/C24H23N5O7S.Na/c25-23(31)21-19-12-14-28(16-6-4-15(5-7-16)27-13-2-1-3-20(27)30)24(32)22(19)29(26-21)17-8-10-18(11-9-17)36-37(33,34)35;/h4-11H,1-3,12-14H2,(H2,25,31)(H,33,34,35);/q;+1/p-1
• InChI key: InChIKey=IIZNDSHJOZRLJA-UHFFFAOYSA-M
• SMILES: NC(=O)c1nn(-c2ccc(OS(=O)(=O)O[Na])cc2)c2c1CCN(c1ccc(N3CCCCC3=O)cc1)C2=O