N-Desmethyl-4-hydroxy Tamoxifen-d5 (1:1 E/Z Mixture)

CAS: 1584173-54-5

Ref. TR-D292044

Product Information

• Name: N-Desmethyl-4-hydroxy Tamoxifen-d5 (1:1 E/Z Mixture)
• Synonyms: 4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl-d5]phenol, (E/Z-Endoxifen-d5, 4OHNDtam-d5
• CAS: 1584173-54-5

Description

Applications A novel active labelled metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),

• Brand: TRC

Chemical properties

• Molecular weight: 378.52
• Formula: C₂₅D₅H₂₂NO₂
• Color/Form: Neat
• InChI: InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/i1D3,3D2
• InChI key: InChIKey=MHJBZVSGOZTKRH-JZSWEIPSSA-N
• SMILES: [2H]C([2H])([2H])C([2H])([2H])/C(=C(\c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1