5-Desthiopropyl-5-hydroxy-ticagrelor

CAS: 1644461-81-3

Ref. TR-D297505

Product Information

• Name: 5-Desthiopropyl-5-hydroxy-ticagrelor
• Synonyms: Ticagrelor Related Compound 15, (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-hydroxy-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
• CAS: 1644461-81-3

Description

Applications 5-Desthiopropyl-5-hydroxy-ticagrelor is a related compound of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).
References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 464.42
• Formula: C₂₀H₂₂F₂N₆O₅
• Color/Form: Neat
• InChI: InChI=1S/C20H22F2N6O5/c21-10-2-1-8(5-11(10)22)9-6-12(9)23-18-15-19(25-20(32)24-18)28(27-26-15)13-7-14(33-4-3-29)17(31)16(13)30/h1-2,5,9,12-14,16-17,29-31H,3-4,6-7H2,(H2,23,24,25,32)/t9-,12+,13+,14-,16-,17+/m0/s1
• InChI key: InChIKey=VIYAQRSGFWADAN-AAIYSHPVSA-N
• SMILES: OCCO[C@H]1C[C@@H](n2nnc3c(N[C@@H]4C[C@H]4c4ccc(F)c(F)c4)nc(O)nc32)[C@H](O)[C@@H]1O