1,2-Dibromo-4,5-Dimethylbenzene

CAS: 24932-48-7

Ref. TR-D425280

Product Information

• Name: 1,2-Dibromo-4,5-Dimethylbenzene
• Synonyms: 4,5-Dibromo-1,2-xylene, 4,5-Dibromo-o-xylene, 1,2-Dibromo-4,5-dimethylbenzene
• CAS: 24932-48-7

Description

Applications 1,2-Dibromo-4,5-dimethylbenzene is used as a reagent in the synthesis of Thalidomide (T338850); an inhibitor of FGF-induced angiogenesis and replication of human immunodeficiency virus type 1. Also a teratogenic sedative and immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.
References Chen, J., et al.: Org. Biomol. Chem., 12, 5578 (2014); D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994); Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993); Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)

• Brand: TRC

Chemical properties

• Molecular weight: 263.96
• Formula: C₈H₈Br₂
• Color/Form: Neat
• InChI: InChI=1S/C8H8Br2/c1-5-3-7(9)8(10)4-6(5)2/h3-4H,1-2H3
• InChI key: InChIKey=BCIDDURGCAHERU-UHFFFAOYSA-N
• SMILES: Cc1cc(Br)c(Br)cc1C