(R)-Diphenyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
CAS:
Ref. TR-D431035
25mg
340.00€
100mg
1,164.00€
250mg
2,261.00€
Product Information
Name:(R)-Diphenyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
Controlled Product
Synonyms:
- [(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid
- Diphenyl Ester
Brand:TRC
Description:Applications (R)-Diphenyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is a reagent for the synthesis of amidate prodrugs of PMEA and PMPA. Also functions as a reagent in the preparation of tenofovir alafenamide fumarate impurity.References Ballatore, C., et al.: Bioorg. Med. Chem. Lett., 11, 1053 (2001); Chen, G., et al.: From Faming Zhuanli Shenqing (2016), CN 105330700 A 20160217
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Chemical properties
Molecular weight:439.4
Formula:C21H22N5O4P
Color/Form:White To Beige
InChI:InChI=1S/C21H22N5O4P/c1-16(12-26-14-25-19-20(22)23-13-24-21(19)26)28-15-31(27,29-17-8-4-2-5-9-17)30-18-10-6-3-7-11-18/h2-11,13-14,16H,12,15H2,1H3,(H2,22,23,24)/t16-/m1/s1
InChI key:InChIKey=XWTDSRIRFPGRAW-MRXNPFEDSA-N
SMILES:C[C@H](Cn1cnc2c(N)ncnc21)OCP(=O)(Oc1ccccc1)Oc1ccccc1
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