3-(Dimethylphenylsilyl)-cyclobutanone

CAS: 847158-84-3

Ref. TR-D432053

Product Information

• Name: 3-(Dimethylphenylsilyl)-cyclobutanone
• Synonyms: 3-(Dimethyl(phenyl)silyl)cyclobutanone

Description

Applications 3-(Dimethylphenylsilyl)-cyclobutanone is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3β inhibitors as anticancer agents.
References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);

• Brand: TRC

Chemical properties

• Molecular weight: 204.34
• Formula: C₁₂H₁₆OSi
• Color/Form: Neat
• InChI: InChI=1S/C12H16OSi/c1-14(2,12-8-10(13)9-12)11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3
• InChI key: InChIKey=UCLQUAUTIGIDGZ-UHFFFAOYSA-N
• SMILES: C[Si](C)(c1ccccc1)C1CC(=O)C1