7-O-2,2-Dichloroethoxycarbonyl Docetaxel

CAS: 158810-72-1

Ref. TR-D434410

Product Information

• Name: 7-O-2,2-Dichloroethoxycarbonyl Docetaxel
• Synonyms: (alphaR,betaS)-beta-[[(1,1-Dimethylethoxy)carbonyl]amino]-alpha-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-4-[[(2,2-dichloroethoxy)carbonyl]oxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester, [2aR-[2aalpha,4beta,4abeta,6beta,9alpha(alphaR,betaS*),11alpha,12alpha,12aalpha,12balpha]]- beta-[[(1,1-Dimethylethoxy)carbonyl]amino]-alpha-hydroxybenzenepropanoic Acid 12b-(Acetyloxy)-12-(benzoyloxy)-4-[[(2,2-dichloroethoxy)carbonyl]oxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester, 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete Benzenepropanoic Acid Deriv.

Description

Applications 7-O-2,2-Dichloroethoxycarbonyl Docetaxel is a metabolite of Docetaxel (D494420); an antineoplastic and antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.
References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991); Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)

• Brand: TRC

Chemical properties

• Molecular weight: 948.83
• Formula: C₄₆H₅₅Cl₂NO₁₆
• Color/Form: Off-White to Light Beige Solid