2-(2,6-Difluoro-4-methoxyphenyl)-2-oxoacetic Acid

CAS: 1183701-25-8

Ref. TR-D447575

Product Information

• Name: 2-(2,6-Difluoro-4-methoxyphenyl)-2-oxoacetic Acid
• Synonyms: 2,6-Difluoro-4-methoxy-α-oxo-benzeneacetic Acid

Description

Applications 2-(2,6-Difluoro-4-methoxyphenyl)-2-oxoacetic Acid is a derivative of 3,5-Difluoroanisole (D445395), which is used in the preparation of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists. Also used in the preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines as orally active phosphodiesterase 10A inhibitors.
References Procopiou, P.A., et al.: J. Med. Chem., 56, 1946 (2013); Malamas, M.S., et al.: J. Med. Chem., 54, 7621 (2011)

• Brand: TRC

Chemical properties

• Molecular weight: 216.138
• Formula: C₉H₆F₂O₄
• Color/Form: Neat
• InChI: InChI=1S/C9H6F2O4/c1-15-4-2-5(10)7(6(11)3-4)8(12)9(13)14/h2-3H,1H3,(H,13,14)
• InChI key: InChIKey=KEHUPPXBYYVOAH-UHFFFAOYSA-N
• SMILES: COc1cc(F)c(C(=O)C(=O)O)c(F)c1