20b-Dihydrocortisone

CAS: 116-59-6

Ref. TR-D450045

Product Information

• Name: 20b-Dihydrocortisone
• Synonyms: Pregn-4-ene-3,11-dione, 17,20,21-trihydroxy-, (20R)-, Pregn-4-ene-3,11-dione, 17,20ß,21-trihydroxy- (6CI,8CI), (20R)-17,20,21-Trihydroxypregn-4-ene-3,11-dione, 17,20ß,21-Trihydroxypregn-4-ene-3,11-dione, 17a,20ß,21-Trihydroxy-4-pregnene-3,11-dione, 20ß-Dihydrocortisone, 20ß-Hydroxycortisone, Pregn-4-en-17a,20ß,21-triol-3,11-dione, Pregn-4-ene-17a,20ß,21-triol-3,11-dione, Reichstein's substance U, 17-Alpha,20-Beta,21-Trihydroxypregn-4-Ene-3,11-Dione

Description

Applications 20β-Dihydrocortisone is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Reach, G., et. al.: Steroids, 30, 621 (1977); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)

• Brand: TRC

Chemical properties

• Molecular weight: 362.46
• Formula: C₂₁H₃₀O₅
• Color/Form: Neat
• InChI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,17-18,22,25-26H,3-8,10-11H2,1-2H3/t14-,15-,17+,18+,19-,20-,21-/m0/s1
• InChI key: InChIKey=XBIDABJJGYNJTK-GNIMZFFESA-N
• SMILES: C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@]2(O)[C@H](O)CO