(R)-1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine

CAS: 1132667-04-9

Ref. TR-D460360

Product Information

• Name: (R)-1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine
• Synonyms: (7R)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine, Ivabradine Impurity 11
• CAS: 1132667-04-9

Description

Applications (R)-1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine is an intermediate in the synthesis of ent-Ivabradine Hydrochloride (I940505), which is the enantiomer of Ivabradine Hydrochloride (I940500); a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Also an antianginal.
References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994); Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998); Borer, J.S., et al.: Circulation, 107, 817 (2003); DiFrancesco, D., et al.: Drugs, 64, 1757 (2004)

• Brand: TRC

Chemical properties

• Molecular weight: 207.27
• Formula: C₁₂H₁₇NO₂
• Color/Form: Pale Yellow Gel
• InChI: InChI=1S/C12H17NO2/c1-13-7-9-4-8-5-11(14-2)12(15-3)6-10(8)9/h5-6,9,13H,4,7H2,1-3H3/t9-/m0/s1