4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid, Disodium Salt

CAS: 67483-13-0

Ref. TR-D460600

Product Information

• Name: 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid, Disodium Salt
• Synonyms: disodium;5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfonatophenyl)ethenyl]benzenesulfonate
• CAS: 67483-13-0

Description

Stability Recommend Desiccate and Storage at -20°C
Applications Stilbene disulfonates have been employed to inhibit anion transport in a large number of mammalian cell types (GABA, Cl-). Some stilbene disulfonates can bind specifically to proteins that are not anion transporters. DIDS reacts with CD4 glycoprotein on T helper lymphocytes and macrophages, blocking HIV type-1 growth at multiple stages of the viral life cycle.Fluorescence: max. Abs. l = 341, max. Em. l = 415 (in water)
References Horie, S., et al.: Res. Comm. Chem. Pathol. Pharmacol., 79, 117 (1993) Mayinger, P. & Meyer, D.I.: EMBO J., 12, 659 (1993); Am. J. Physiol. 262, C803 (1992); J. Biol. Chem. 266, 13355 (1991).

• Brand: TRC

Chemical properties

• Molecular weight: 498.48
• Formula: C₁₆H₈N₂Na₂O₆S₄
• Color/Form: Neat
• InChI: InChI=1S/C16H10N2O6S4.2Na/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24;;/h1-8H,(H,19,20,21)(H,22,23,24);;/q;2*+1/p-2/b2-1+
• SMILES: O=S(=O)([O-])c1cc(N=C=S)ccc1/C=C/c1ccc(N=C=S)cc1S(=O)(=O)[O-].[Na+].[Na+]