2-(Dimethylamino)guanosine-d6

CAS: 2140-67-2

Ref. TR-D460852

Product Information

• Name: 2-(Dimethylamino)guanosine-d6
• Synonyms: N,N-Dimethylguanosine-d6, 2,2-Dimethylguanosine-d6, 2-Dimethylamino-6-oxypurine Riboside-d6, N2,N2-Dimethylguanosine-d6, 2,2-Dimethylguanosine, 2-Dimethylamino-6-oxypurine riboside, Guanosine, N,N-dimethyl-, N(2),N(2)-Dimethylguanosine, N,N-dimethylguanosine, N²,N²-Dimethylguanosine
• CAS: 2140-67-2

Description

Applications 2-(Dimethylamino)guanosine-d6 is deuterium labeled 2-(Dimethylamino)guanosine (D460850), which can be used to investigate the mechanism of 2'-deoxyoxanosine formation from 2'-deoxyguanosine and nitrous acid. In addition, 2-(Dimethylamino)guanosine can also be employed in mass spectrometry to quantify tRNA modifications related to cellular stress response in Saccharomyces cerevisiae.
References Suzuki, T., et al.: Nucleic Acids Res 28, 544 (2000); Chan, C. T. et al.: PLoS Genet 6, e1001247 (2010).

• Brand: TRC

Chemical properties

• Molecular weight: 317.33
• Formula: C₁₂H₁₁D₆N₅O₅
• Color/Form: White to Off-White Solid
• InChI: InChI=1S/C12H17N5O5/c1-16(2)12-14-9-6(10(21)15-12)13-4-17(9)11-8(20)7(19)5(3-18)22-11/h4-5,7-8,11,18-20H,3H2,1-2H3,(H,14,15,21)/t5-,7-,8-,11-/m1/s1/i1D3,2D3
• InChI key: InChIKey=RSPURTUNRHNVGF-PPZQBEDYSA-N
• SMILES: [2H]C([2H])([2H])N(c1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1)C([2H])([2H])[2H]