4-(N-1-Dimethylaminonaphthalene-5-sulfonylamino)phenyl Isothiocyanate

CAS: 102417-94-7

Ref. TR-D461000

Product Information

• Name: 4-(N-1-Dimethylaminonaphthalene-5-sulfonylamino)phenyl Isothiocyanate
• Synonyms: 5-(dimethylamino)-N-(4-isothiocyanatophenyl)naphthalene-1-sulfonamide, Dansylamino-PITC, 4-[5-(Dimethylamino)-1-naphthalenesulfonylamino]phenyl isothiocyanate

Description

Stability Light Sensitive; Store at -20°C and Desicate.
Applications A fluorescent PITC homologue Edman-type reagent with similar coupling efficiency and repetitive degradation yield to those of PITC. Naphthalene derivatives may be particularly useful for preparing fluorescent drug or ligand analogues that are expected to bind to hydrophobic sites in proteins or membranes. The lipophilicity of these reagents may also facilitate the labelling of sites within the membrane-spanning portions of cellular proteins.Fluorescence: max. Abs. l = 335nm, max. Em. l = 536nm (in methanol)
References Gordon, E., et al.: Chem. Biol., 7, 9 (2000), Nagahori, N., et al.: ChemBioChem, 3, 836 (2002), Mrksich, M., et al.: Chem. Biol., 11, 739 (2004),

• Brand: TRC

Chemical properties

• Molecular weight: 383.49
• Formula: C₁₉H₁₇N₃O₂S₂
• Color/Form: Neat
• InChI: InChI=1S/C19H17N3O2S2/c1-22(2)18-7-3-6-17-16(18)5-4-8-19(17)26(23,24)21-15-11-9-14(10-12-15)20-13-25/h3-12,21H,1-2H3
• InChI key: InChIKey=MZGXHCHKGRQLHR-UHFFFAOYSA-N
• SMILES: CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(N=C=S)cc3)cccc12