Des[9-((3R,4R)-3-Methoxy-4-Hydroxy-cyclohexyl)-(1R,4R,8R)-2,4,8-Trimethyl-1-Hydroxy-5-Oxo-nona-2,6-dien-1-yl] seco Rapamycin

CAS: 147438-30-0

Ref. TR-D461585

Product Information

• Name: Des[9-((3R,4R)-3-Methoxy-4-Hydroxy-cyclohexyl)-(1R,4R,8R)-2,4,8-Trimethyl-1-Hydroxy-5-Oxo-nona-2,6-dien-1-yl] seco Rapamycin
• Synonyms: (S)-1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic acid
• CAS: 147438-30-0

Description

Applications (2S)​-1-​[2-​[(2R,​3R,​6S)​-​6-​[(2S,​3E,​5E,​7E,​9S,​11R)​-​2,​13-​Dimethoxy-​3,​9,​11-​trimethyl-​12-​oxo-​3,​5,​7-​tridecatrien-​1-​yl]​tetrahydro-​2-​hydroxy-​3-​methyl-​2H-​pyran-​2-​yl]​-​2-​oxoacetyl]​-​2-​piperidinecarboxylic Acid is an impurity of Sirolimus (R124000) which is an immunosuppressant drug used to prevent rejection in organ transplantation.
References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004)

• Brand: TRC

Chemical properties

• Molecular weight: 591.73
• Formula: C₃₂H₄₉NO₉
• Color/Form: Neat
• InChI: InChI=1S/C32H49NO9/c1-21(18-23(3)27(34)20-40-5)12-8-7-9-13-22(2)28(41-6)19-25-16-15-24(4)32(39,42-25)29(35)30(36)33-17-11-10-14-26(33)31(37)38/h7-9,12-13,21,23-26,28,39H,10-11,14-20H2,1-6H3,(H,37,38)/b9-7+,12-8+,22-13+/t21-,23-,24-,25+,26+,28+,32-/m1/s1
• SMILES: CSc1nc(NC2CCCC2)c([N+](=O)[O-])c(NC2CCCC2)n1