4-[4-[4-(Diphenylmethylene)-1-piperidinyl]-1-hydroxybutyl]-a,a-dimethyl-benzeneacetic Acid

CAS: 1187954-57-9

Ref. TR-D492020

Product Information

• Name: 4-[4-[4-(Diphenylmethylene)-1-piperidinyl]-1-hydroxybutyl]-a,a-dimethyl-benzeneacetic Acid
• Synonyms: Benzeneacetic acid, 4-[4-[4-(diphenylmethylene)-1-piperidinyl]-1-hydroxybutyl]-a,a-dimethyl-, 2-[4-[(1RS)-4-[4-(Diphenylmethyl-idene)piperidin-1-yl]-1-hydroxybutyl]phenyl]-2-methylpropanoic Acid
• CAS: 1187954-57-9

Description

Applications 4-[4-[4-(Diphenylmethylene)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethyl-benzeneacetic acid is an impurity of fexofenadine (F322490), the active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist.
References Pratt, E., et al.: Diabet Med., 18, 515 (2001), Mizutani, N., et al.: J. Pharmacol. Sci., 93, 437 (2003), Scadding, G., et al.: Clin. Drug Invest., 25, 153 (2005), Asai, M., et al.: N. Engl. J. Med., 354, 307 (2006),

• Brand: TRC

Chemical properties

• Molecular weight: 483.64
• Formula: C₃₂H₃₇NO₃
• Color/Form: Neat
• InChI: InChI=1S/C32H37NO3/c1-32(2,31(35)36)28-17-15-24(16-18-28)29(34)14-9-21-33-22-19-27(20-23-33)30(25-10-5-3-6-11-25)26-12-7-4-8-13-26/h3-8,10-13,15-18,29,34H,9,14,19-23H2,1-2H3,(H,35,36)
• InChI key: InChIKey=BRVDCQYIFNJGSU-UHFFFAOYSA-N
• SMILES: CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(=C(c3ccccc3)c3ccccc3)CC2)cc1