Dorzolamide Maleic Acid Adduct

Ref. TR-D535105

Product Information

• Name: Dorzolamide Maleic Acid Adduct
• Synonyms: 2-(Ethyl((4S,6S)-6-methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)amino)succinic Acid

Description

Applications Dorzolamide Maleic Acid Adduct, is the isomeric adduct resulting from the nucleophilic addition of Dorzolamide (D535100) to Maleic Acid. Dorzolamide, is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour. It is used in the form of eye drops.
References Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991), Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991), Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991), Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998),

• Brand: TRC

Chemical properties

• Molecular weight: 440.51
• Formula: C₁₄H₂₀N₂O₈S₃
• Color/Form: White To Off-White
• InChI: InChI=1S/C14H20N2O8S3/c1-3-16(10(13(19)20)6-11(17)18)9-4-7(2)26(21,22)14-8(9)5-12(25-14)27(15,23)24/h5,7,9-10H,3-4,6H2,1-2H3,(H,17,18)(H,19,20)(H2,15,23,24)/t7-,9-,10?/m1/s1
• InChI key: InChIKey=VXRRDUKDKBFDHS-QVSNTAFXSA-N
• SMILES: CCN(C(CC(=O)O)C(=O)O)[C@@H]1C[C@@H](C)S(=O)(=O)c2sc(S(N)(=O)=O)cc21