Diltiazem Sulfone N-Oxide

Ref. TR-D596825

Product Information

• Name: Diltiazem Sulfone N-Oxide
• Synonyms: 2-((2S,3S)-3-Acetoxy-2-(4-methoxyphenyl)-1,1-dioxido-4-oxo-3,4-dihydrobenzo[b][1,4]thiazepin-5(2H)-yl)-N,N-dimethylethanamine Oxide

Description

Applications Diltiazem Sulphone N-Oxide is an analogue of Diltiazem (D460620), a calcium channel blocker with vasodilating activity. Anti-anginal; anti-hypertensive; anti-arrhythmic (class IV), and it can be administered in adjunctive therapy to treat tachycardia and tachyarrhythmias in patients with hyperthyroidism if beta-blockers cannot be used
References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971);Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998);Hansson, L., et al.: Lancet, 356, 359 (2000);Fihn, D., et. al.: Circulation, 126, 354 (2012)

• Brand: TRC

Chemical properties

• Molecular weight: 462.516
• Formula: C₂₂H₂₆N₂O₇S
• Color/Form: Neat
• InChI: InChI=1S/C22H26N2O7S/c1-15(25)31-20-21(16-9-11-17(30-4)12-10-16)32(28,29)19-8-6-5-7-18(19)23(22(20)26)13-14-24(2,3)27/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
• SMILES: COc1ccc([C@H]2[C@@H](OC(C)=O)C(=O)N(CC[N+](C)(C)[O-])c3ccccc3S2(=O)=O)cc1