Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

CAS: 160844-75-7

Ref. TR-E907780

Product Information

• Name: Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
• Synonyms: 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester, 2-(3-Cyano-4-Isobutoxyphenyl)-4-Methylthiazole-5-Carboxylic Acid Ethyl Ester, 2-[3-Cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazole Carboxylic Acid Ethyl Ester, 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester, Ethyl 2-(3-Cyano-4-IsobutoxyPhenyl)-4-MethylThiazole-5-Carboxylate, Ethyl 2-[3-Cyano-4-(2-Methylpropoxy)Phenyl]-4-Methyl-1,3-Thiazole-5-Carboxylate, Ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylate, Febuxostat N-5, Febuxostat intermediates-2, Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Description

Applications Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)

• Brand: TRC

Chemical properties

• Molecular weight: 344.43
• Formula: C₁₈H₂₀N₂O₃S
• Color/Form: Neat
• InChI: InChI=1S/C18H20N2O3S/c1-5-22-18(21)16-12(4)20-17(24-16)13-6-7-15(14(8-13)9-19)23-10-11(2)3/h6-8,11H,5,10H2,1-4H3
• SMILES: CCOC(=O)c1sc(-c2ccc(OCC(C)C)c(C#N)c2)nc1C