9-​Ethyl-​8-​iodo-​6,​6-​dimethyl-​11-​oxo-​6,​11-​dihydro-​5H-​benzo[b]​carbazole-​3-​carbonitrile

CAS: 1256584-80-1

Ref. TR-E918370

Product Information

• Name: 9-​Ethyl-​8-​iodo-​6,​6-​dimethyl-​11-​oxo-​6,​11-​dihydro-​5H-​benzo[b]​carbazole-​3-​carbonitrile
• Synonyms: 9-Ethyl-6,11-dihydro-8-iodo-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

Description

Stability Light Sensitive
Applications 9-​Ethyl-​8-​iodo-​6,​6-​dimethyl-​11-​oxo-​6,​11-​dihydro-​5H-​benzo[b]​carbazole-​3-​carbonitrile is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. Process impurity.
References Kinoshita, K. et al.: J. Med. Chem., 64, 6286 (2011); Sakamoto, H., et al.: Cancer Cell., 19, 679 (2011); Kinoshita, K., et al.: Bio-org. Medn., 20, 1271 (2012);

• Brand: TRC

Chemical properties

• Molecular weight: 440.28
• Formula: C₂₁H₁₇IN₂O
• Color/Form: Neat
• SMILES: CCc1cc2c(cc1I)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O