(6Alpha,11Beta,16Beta)-17,21-[(1-Ethoxypropylidene)bis(oxy)]-6,9-difluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

CAS: 924726-88-5

Ref. TR-E924725

Product Information

• Name: (6Alpha,11Beta,16Beta)-17,21-[(1-Ethoxypropylidene)bis(oxy)]-6,9-difluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

Description

Applications (6α,11β,16β)-17,21-[(1-Ethoxypropylidene)bis(oxy)]-6,9-difluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione is an intermediate in the synthesis of Diflorasone 17-propionate-21-mesylate (D445513). which is an impurity related to Halobetasol propionate, which belongs to a Class I topical synthetic corticosteroids used to treat a variety of skin conditions, for example, eczema, dermatitis, allergies and rash, in which it reduces swelling, itching and redness.
References Nalwade, Santaji., et al.: J Chromatogr Sci., 53, 127 (2015);

• Brand: TRC

Chemical properties

• Molecular weight: 494.57
• Formula: C₂₇H₃₆F₂O₆
• Color/Form: Neat
• InChI: InChI=1S/C27H36F2O6/c1-6-25(33-7-2)34-14-22(32)27(35-25)15(3)10-17-18-12-20(28)19-11-16(30)8-9-23(19,4)26(18,29)21(31)13-24(17,27)5/h8-9,11,15,17-18,20-21,31H,6-7,10,12-14H2,1-5H3/t15-,17-,18-,20-,21-,23-,24-,25?,26-,27-/m0/s1
• InChI key: InChIKey=ZTAIHXMTPPBFLW-BJAJCIPTSA-N
• SMILES: CCOC1(CC)OCC(=O)[C@@]2(O1)[C@@H](C)C[C@H]1[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C