2-[(5-Fluoresceinyl)aminocarbonyl]ethyl Methanethiosulfonate

CAS: 351330-42-2

Ref. TR-F510000

Product Information

• Name: 2-[(5-Fluoresceinyl)aminocarbonyl]ethyl Methanethiosulfonate
• Synonyms: Methanesulfonothioic Acid S-[3-[(3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]-3-oxopropyl] Ester, MTS-4-Fluorescein
• CAS: 351330-42-2

Description

Applications A thiol specific fluorescent probe useful for ion channel and protein topology research. The recently available MTS-fluorophores may find application in the real-time monitoring of conformational changes, since fluorophores coupled to introduced cysteines can change their fluorescence during a conformational change. Fluorescence lifetime may also yield information regarding distances and molecular motion in a protein molecule.Fluorescence: max. Abs. 492nm; max. Em. 515nm; e x 10-3: 75
References Mannuzzu, L.M., et al.: Science, 271, 213 (1996), Goulett, C.C., et al.: JBC, 273, 45, 30012 (1998), Adams, C.M., et al.: JBC, 273, 46, 30204 (1998)

• Brand: TRC

Chemical properties

• Molecular weight: 513.54
• Formula: C₂₄H₁₉NO₈S₂
• Color/Form: Yellow to Pale Orange to Red Solid
• InChI: InChI=1S/C24H19NO8S2/c1-35(30,31)34-9-8-22(28)25-13-2-5-17-16(10-13)23(29)33-24(17)18-6-3-14(26)11-20(18)32-21-12-15(27)4-7-19(21)24/h2-7,10-12,26-27H,8-9H2,1H3,(H,25,28)
• InChI key: InChIKey=POOIBGNQWPPXKY-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)SCCC(=O)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21