10-Formyl-7,8-dihydro Folic Acid (>85%) Disodium Salt

CAS: 28459-40-7

Ref. TR-F700455

Product Information

• Name: 10-Formyl-7,8-dihydro Folic Acid (>85%) Disodium Salt
• Synonyms: N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-L-glutamic Acid Disodium Salt, N-[p-[N-[(2-Amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl], L-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-, N-Formyl-7,8-dihydrofolic acid, N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-L-glutamic acid, Glutamic acid, N-[p-[N-[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-, L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-

Description

Stability Temperature Sensitive
Applications 10-Formyl-7,8-dihydrofolic acid is a novel folate found in methotrexate-treated cells. 10-Formyldihydrofolate (H2folate) has not been found as a component of intracellular folates in normal tissues but has been identified in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells.
References Barford, P.A., et al.: Br. J. Cancer, 1978, 38, 122 (1978); Baggott, J.E., et al.: Biochemistry, 1979, 18, 1036 (1979); Hahm, S., et al.: Biochemistry, 33, 1473 (1994),

• Brand: TRC

Chemical properties

• Molecular weight: 515.39
• Formula: C₂₀H₁₉N₇Na₂O₇
• Color/Form: Neat
• InChI: InChI=1S/C20H21N7O7.2Na/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30;;/h1-4,9,13H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32);;/q;2*+1/p-2
• InChI key: InChIKey=IWYDZMMSLIRSRL-GXKRWWSZSA-L
• SMILES: Nc1nc(=O)c2c([nH]1)NCC(CN(C=O)c1ccc(C(=O)N[C@@H](CCC(=O)O[Na])C(=O)O[Na])cc1)=N2